Grant✓ Small businesses may apply
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
National Institutes of Health
Award ceiling
$3,000,000
- Opportunity #
- PAR-25-446
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.279
- Status
- posted
- Posted
- Sep 10, 2025
- Closes
- Aug 21, 2028
- Funding instrument
- Cooperative Agreement
- Category
- Education, Health
- Cost sharing required
- No
Who can apply
- •County governments
- •For profit organizations other than small businesses
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Special district governments
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •Small businesses
- •State governments
- •Independent school districts
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •Private institutions of higher education
- •Public and State controlled institutions of higher education
- •City or township governments
- •Public housing authorities/Indian housing authorities
- •Native American tribal governments (Federally recognized)
- •Native American tribal organizations (other than Federally recognized tribal governments)
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Synopsis
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
Contact
National Institutes of Health · grantsinfo@nih.gov