Grant✓ Small businesses may apply
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
National Institutes of Health
- Opportunity #
- PAR-25-450
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.350, 93.865
- Status
- posted
- Posted
- Sep 22, 2025
- Closes
- Jul 20, 2028
- Funding instrument
- Grant
- Category
- Health, Income Security and Social Services
- Cost sharing required
- No
Who can apply
- •State governments
- •County governments
- •City or township governments
- •Public and State controlled institutions of higher education
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Independent school districts
- •Small businesses
- •For profit organizations other than small businesses
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •Native American tribal organizations (other than Federally recognized tribal governments)
- •Private institutions of higher education
- •Special district governments
- •Native American tribal governments (Federally recognized)
- •Public housing authorities/Indian housing authorities
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Synopsis
This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling efficient and effective movement of candidate therapeutics or diagnostics toward clinical trials, and to increase their likelihood of success. This could be through the development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.
Contact
National Institutes of Health · grantsinfo@nih.gov