Grant✓ Small businesses may apply
NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)
National Institutes of Health
- Opportunity #
- PAR-25-447
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.837, 93.838, 93.839, 93.840, 93.233
- Status
- posted
- Posted
- Sep 22, 2025
- Closes
- May 8, 2028
- Funding instrument
- Grant
- Category
- Health
- Cost sharing required
- No
Who can apply
- •City or township governments
- •Native American tribal governments (Federally recognized)
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •Small businesses
- •Public housing authorities/Indian housing authorities
- •Native American tribal organizations (other than Federally recognized tribal governments)
- •Independent school districts
- •County governments
- •Private institutions of higher education
- •Public and State controlled institutions of higher education
- •Special district governments
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •For profit organizations other than small businesses
- •State governments
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Synopsis
This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine
Contact
National Institutes of Health · grantsinfo@nih.gov