Grant✓ Small businesses may apply
Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
National Institutes of Health
- Opportunity #
- PAR-27-081
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.866, 93.242, 93.867, 93.279
- Status
- posted
- Posted
- May 4, 2026
- Closes
- Mar 5, 2027
- Funding instrument
- Grant
- Category
- Health
- Cost sharing required
- No
Who can apply
- •For profit organizations other than small businesses
- •Private institutions of higher education
- •Small businesses
- •State governments
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •Special district governments
- •Public and State controlled institutions of higher education
- •Native American tribal governments (Federally recognized)
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •City or township governments
- •Independent school districts
- •County governments
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Public housing authorities/Indian housing authorities
- •Native American tribal organizations (other than Federally recognized tribal governments)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Contact
National Institutes of Health · NIA-NOFO-Scientific@nih.gov